The Effect of Aminoguanidine on the Oxidation of Formaldehyde by Rat Liver by Frederick Bernheim

نویسنده

  • FREDERICK BERNHEIM
چکیده

Formaldehyde was shown to be a normal metabolite when Handler, Bernheim, and Klein (1) found sarcosine oxidase which catalyzes the oxidative demethylation of sarcosine to glycine and formaldehyde. Sakami (2), Welsh and Sakami (3), and Stekol et al. (4) have recently presented evidence that formate may provide the animal with necessary methyl groups. It was therefore of interest to investigate the oxidation of formaldehyde to formic acid in vitro in animal tissue. It apparently has been assumed that xanthine oxidase or aldehyde oxidase is responsible for its metabolism.

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تاریخ انتشار 2003